Ongoing Research

Ongoing Research

Current Research

BRAIN-2
A national study (sponsored by NIH-NIA) in which deceased patients’ families are consenting to provide a priceless donation to science to study COVID-19 effect on the brain.
BRAIN-ICU-2
This is an exciting and upcoming study designed to understand the link between delirium and dementia after critical illness.
COPE-iOS
A study of the effects of brain training and physical exercise on recovery after major surgery.
ECID
The Early Cognitive Intervention in Delirium (ECID) study is a randomized control trial designed to determine if early (<24 hours) cognitive training and rehabilitation improve 4-month global cognition in older delirious patients with and without Alzheimer’s disease and related dementias.
FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial
This Department of Defense (DoD) funded randomized clinical trial is to determine about if plasma transfusion can improve outcomes after traumatic brain injury.
INMO
NIH-funded observational study examining EEG signatures of ICU delirium and post-ICU cognitive impairment
INSIGHT-ICU
An ongoing comprehensive long-term cognitive impairment study after traumatic injury and critical illness.
INSPiRE-ICU1
Industry-funded multicenter randomized controlled trial of inhaled isoflurane compared to intravenous propofol for sedation in the ICU
ISOLATE-ICU
A national study of the effect of COVID-related isolation policies on patients, families, and healthcare providers in the ICU
MENDING
A multicenter study of the role of a new drug for ICU delirium in COVID-19 patients
mini-MENDS
A randomized controlled trial to determine the best sedative medication to reduce delirium and improve functional and behavioral recovery in pediatric patients.
MOSAIC
An ongoing observational study of the association between activity and physical and cognitive function in ICU survivors.
Mynd-Health
Pilot study, funded by the Brain and Behavior Research Foundation, examining feasibility of delivering remote neurofeedback training (Myndlift) to ICU survivors for improved psychological outcomes
Prevent
A Department of Defense (DoD) randomized clinical trial of Neuromuscular electrical stimulation of abdominal muscles to assist ventilator weaning in critically ill patients
RETURN-III
NIH/VA-Merit funded Randomized Controlled Trial on computerized cognitive rehabilitation after critical illness
Reverse-LC
NIH funded Randomized Controlled Trial of an Immunomodulator (Baricitinib) for Patients with Long COVID
RSI
The Randomized trial of Sedative choice for Intubation (RSI) trial is a randomized trial comparing ketamine versus etomidate’s effect on 1-month mortality and 12-month post-traumatic stress disorder symptoms in critically ill adults who are receiving a breathing tube in the emergency department or intensive care unit.
TAP
This is an industry-funded (CSL Behring) prospective, international, multicenter, randomized clinical trial to investigate the efficacy and safety of a 4-factor prothrombin complex concentrate ([Kcentra® / Beriplex®]) in subjects who have traumatic injury, with confirmed or suspected acute major ble

Archived Studies

CADUCEUS
An ancillary study of inflammation levels in the blood of critically ill patients.
CO-PILOT
An ancillary study to determine how oxygen levels during mechanical ventilation affect long-term cognition.
COVID-D
An International study of the risk factors and epidemiology of delirium and coma in COVID-19 patients while admitted to the ICU
DeCat
An investigational cohort study of delirium and catatonia in critically ill patients.
MENDS2
A randomized controlled trial to determine the best sedative medication to reduce delirium and improve survival and long-term brain function in ventilated septic patients.
MIND-USA
After 40 years of using antipsychotics to treat delirium in millions of ICU patients, the MIND-USA finally provides a placebo-controlled treatment trial to answer the question: Do these medications reduce delirium and improve other clinical outcomes better than sugar water in ICU patients?
ORCHID-BUD
A national study (sponsored by NIH-NIA) to understand long-term cognitive function, PTSD, and depression in COVID-19 survivors
SCOPE
A randomized controlled trial to evaluate the effect of specialist palliative care on quality of life for patients undergoing major abdominal operations for cancer.