Ongoing Research

Ongoing Research

Current Research

BRAIN-2
A national study (sponsored by NIH-NIA) in which deceased patients’ families are consenting to provide a priceless donation to science to study COVID-19 effect on the brain
BRAIN-ICU-2
This is an exciting and upcoming study designed to understand the link between delirium and dementia after critical illness.
COPE-iOS
A study of the effects of brain training and physical exercise on recovery after major surgery.
INSIGHT-ICU
An ongoing comprehensive long-term cognitive impairment study after traumatic injury and critical illness.
ISOLATE-ICU
A national study of the effect of COVID-related isolation policies on patients, families, and healthcare providers in the ICU
MENDING
A multicenter study of the role of a new drug for ICU delirium in COVID-19 patients
mini-MENDS
A randomized controlled trial to determine the best sedative medication to reduce delirium and improve functional and behavioral recovery in pediatric patients.
MOSAIC
An ongoing observational study of the association between activity and physical and cognitive function in ICU survivors.

Archived Studies

CADUCEUS
An ancillary study of inflammation levels in the blood of critically ill patients.
CO-PILOT
An ancillary study to determine how oxygen levels during mechanical ventilation affect long-term cognition.
COVID-D
An International study of the risk factors and epidemiology of delirium and coma in COVID-19 patients while admitted to the ICU
DeCat
An investigational cohort study of delirium and catatonia in critically ill patients.
MENDS2
A randomized controlled trial to determine the best sedative medication to reduce delirium and improve survival and long-term brain function in ventilated septic patients.
MIND-USA
After 40 years of using antipsychotics to treat delirium in millions of ICU patients, the MIND-USA finally provides a placebo-controlled treatment trial to answer the question: Do these medications reduce delirium and improve other clinical outcomes better than sugar water in ICU patients?
ORCHID-BUD
A national study (sponsored by NIH-NIA) to understand long-term cognitive function, PTSD, and depression in COVID-19 survivors
SCOPE
A randomized controlled trial to evaluate the effect of specialist palliative care on quality of life for patients undergoing major abdominal operations for cancer.