Ongoing Research

MIND-USA

After 40 years of using antipsychotics to treat delirium in millions of ICU patients, the MIND-USA finally provides a placebo-controlled treatment trial to answer the question: Do these medications reduce delirium and improve other clinical outcomes better than sugar water in ICU patients?

COPE

A study of the effects of prehabilitation on physical and cognitive recovery in surgery patients.

MOSAIC

An ongoing observational study of the association between activity and physical and cognitive function in ICU survivors.

CADUCEUS

An ancillary study of inflammation levels in the blood of critically ill patients.

BRAIN-ICU-2

This is an exciting and upcoming study designed to understand the link between delirium and dementia after critical illness.

mini-MENDS

A randomized controlled trial to determine the best sedative medication to reduce delirium and improve functional and behavioral recovery in pediatric patients.

DeCat

An ongoing investigational cohort study of delirium and catatonia in critically ill patients.

SCOPE

An ongoing randomized controlled trial to evaluate the effect of specialist palliative care on quality of life for patients undergoing major abdominal operations for cancer.

MENDS2

An ongoing randomized controlled trial to determine the best sedative medication to reduce delirium and improve survival and long-term brain function in ventilated septic patients.

INSIGHT-ICU

An ongoing comprehensive long-term cognitive impairment study after traumatic injury and critical illness.