COVID-19 and CIBS Center
Neurotropism of coronaviridae (CoVs) is known to have occurred in both SARS and MERS epidemics. SARS-CoV-2 closely shares the viral structure and pathobiology of SARS-CoV and MERS-CoV.
The intense cough, ventilator dyssynchrony, and infectious potential reported in COVID-19 patients begets management with large quantities of sedatives, immobilization and social isolation. Thus, COVID-19 is a perfect storm yielding an immense burden of delirium (which drives subsequent dementia) and PICS-related cognitive and mental health disabilities, leading to a widespread emerging public health crisis.
At the CIBS Center we will be studying the cognitive function and physical outcomes of COVID-19 survivors to understand the relationship between COVID-19 and long-term health from the pandemic. It may be that the dementia seen after critical illness, that we already study, could be made worse for COVID-19 patients.