Christopher G. Hughes, MD
Lead, Biomarkers Core
Dr. Christopher G. Hughes is an Associate Professor in the Department of Anesthesiology, Division of Anesthesia Critical Care Medicine at Vanderbilt University Medical Center. He graduated with a Bachelor of Science in Biochemistry summa cum laude from Indiana University in 2001 and a Doctor of Medicine degree from Indiana University School of Medicine in 2005 as a member of the Alpha Omega Alpha Honor Medical Society. He then completed residency in Anesthesiology, including a year as Chief Resident, in 2009 and critical care fellowship in 2010 at Vanderbilt, subsequently joining the faculty in 2010. He is the Program Director for the Anesthesia Critical Care Medicine Fellowship and is the Chair of the Procedural Sedation Committee at Vanderbilt University Medical Center.
Dr. Hughes’ primary research focuses on the roles of endothelial dysfunction and blood brain barrier injury in cognitive dysfunction after acute medical and surgical illness and designing therapeutic regimens that modify these pathways to improve patient outcomes. He has been the principal investigator of multidisciplinary studies examining the role of the endothelium in brain dysfunction and has authored numerous manuscripts on brain dysfunction in critical illness, including the first study to demonstrate the association of endothelial dysfunction with acute brain dysfunction. His ongoing projects are evaluating the mechanistic roles of endothelial activation, blood brain barrier and brain injury, and neuroinflammation in delirium and long-term cognitive impairment after critical illness in the elderly. In addition, Dr. Hughes is the Vanderbilt site principal investigator for the MENDS 2 study of dexmedetomidine vs. propofol for sedation of septic patients on mechanical ventilation. He has received funding from a Foundation for Anesthesia Education and Research Mentored Research Training Grant, multiple Clinical and Translational Science Awards, American Geriatrics Society Jahnigen Career Development Award, and a National Institute on Aging GEMSSTAR R03. For more details of his work, please contact him for a copy of his Curriculum Vitae.