1959

Delirium, a syndrome of cerebral insufficiency

Engel and Romano

The Journal of Neuropsychiatry and Clinical Neurosciences, 1959

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The problem of delirium is far from an academic one. Not only does the presence of delirium often complicate and render more difficult the treatment of a serious illness, but also it carries the serious possibility of permanent irreversible brain damage.
1978

Maya Angelou

Teresa Martin

1996
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Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously

Ely

The New England Journal of Medicine, Dec. 1996

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2000
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Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation

Kress

The New England Journal of Medicine, May 2000

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Karras

Marcus Cobb holding his own heart

Danny West teaching med students in his leopard skin bra

2001
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Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)

Ely

JAMA, Dec. 2001

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2003

Monitoring sedation status over time in ICU patients. Reliability and validity of the Richmond Agitation-Sedation Scale (RASS)

Ely

JAMA, Jun. 2003

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2004
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Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

Ely

JAMA, Apr 2004

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Ray Fugate

Lovemore Gororo

2007
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Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

Pandharipande

JAMA Dec. 2007

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Pratik Pandharipande, MD, MSCI

2008
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Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

Girard

The Lancet, Jan. 2008

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2009
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Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial

Riker

JAMA, Feb. 2009

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Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

Schweikert

The Lancet, May 2009

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2010
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A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial

Strøm

The Lancet, Feb. 2010

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Cottage of Hans Christian Anderson

Thomas Strøm, MD

Little Mermaid Gazing Towards the Baltic Sea

Copenhagen, Denmark

Chris Perme, PT, CCS, FCCM

Heidi Engel, PT, DPT

Rob Harmer and Family

Sarah Beth Miller

Steve Edmonson

Michael Merzenich, PhD

Adam Gazzaley, MD, PhD

2017
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Improving hospital survival and reducing brain dysfunction at seven California community hospitals: Implementing PAD Guidelines via the ABCDEF bundle in 6,064 patients

Barnes-Daly

Critical Care Medicine, Feb. 2017

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2018
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Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

Girard

The New England Journal of Medicine, Oct. 2018

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2019
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Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults

Pun

Critical Care Medicine, Jan. 2019

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John Prine

Titus Lansing with his family

Colonel Victor Correa

Jimmie Johnson and Johnnie Blackwell

Jimmie Johnson with shackles removed

Phillip and Mary Hill

Doyle "DT" and Virginia Stevens

Clementine Hunter

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