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Prevention and Treatment Delirium

S. K. Inouye, S. T. Bogardus, Jr., P. A. Charpentier, L. Leo-Summers, D. Acampora, T. R. Holford, and L. M. Cooney, Jr. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340 (9):669-676, 1999.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10053175

M. Lundstrom, A. Edlund, S. Karlsson, B. Brannstrom, G Bucht, and Y. Gustafson. A multifactorial intervention program reduces the duration of delirium,, length of hospitalization, and mortality in delirious patients. JAGS 53:622-628, 2005.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15817008

Skrobik Y, Bergeron N, Dumont M, Gottfried SB. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med 2004; 30:444-449
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14685663

W. Breitbart, R. Marotta, M. M. Platt, H. Weisman, M. Derevenco, C. Grau, K. Corbera, S. Raymond, S. Lund, and P. Jacobsen. A Double-Blind Trial of Haloperidol, Chlorpromazine, and Lorazepam in the Treatment of Delirium in Hospitalized AIDS Patients. American Journal of Psychiatry February 153 (2):231-237, 1996.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8561204

Ruth M, Locsin R. The effect of music listening on acute confusion and delirium in elders undergoing elective hip and knee surgery. J Clin Nurs 2004;13:91-96.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15724823

Hans CS, Kim YK. A double-blind trial of risperidone and haloperidol for the treatment of delirium. Psychosomatics. 2004;45:297-301.

Weber JB, Coverdale JH, Kunik ME. Delirium: current trends in prevention and treatment. Intern Med J. 2004;34:115-21.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15030459

W. Breitbart. Treatment of delirium in cancer patients with the atypical antipsychotic olanzapine. Paper presented at the Annual Meeting of the Academy of Psychosomatic Medicine, Palm Springs, CA.November, 2000.

E. B. Milbrandt, A. Kersten, L. Kong, L. A. Weissfeld, G. Clermont, M. P. Fink, and D. C. Angus. Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med 33 (1):226-229, 2005.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15644675

Cole MG, Primeau F, McCusker J. Effectiveness of interventions to prevent delirium in hospitalized patients: a systemic review. Can Med Assoc J 1996; 155:1263-1268.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8911292

Gustafson Y, Brannstrom B, Berggren D, Ragnarsson JI, Sigaard J, Bucht G et al. A geriatric anesthesiologic program to reduce acute confusional states in elderly patients treated for femoral neck fracture. Journal America Geriatrics Soc 1991; 39:655-662.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2061530

Marcantonio ER, Flacker JM, Wright RJ, Resnick NM. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 2001; 49(5):516-522.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11380742

Vanderbilt University Medical Center
Veterans Affairs TN Valley Geriatric Research Education and Clinical Center (GRECC)